ETX0282 is an orally active prodrug, with its active form being ETX1317. ETX0282 and ETX1317 are beta-lactamase inhibitors of the dioxolane-dibenzo-p-heptane (DBO) type. ETX0282 exhibits high stability during intestinal absorption and can be efficiently converted into ETX1317 in the liver. ETX0282 alone has no bactericidal activity, but in a mouse model of neutropenic thigh infection, it can significantly reduce bacterial load when used in combination with Cefpodoxime Proxetil (HY-N7101). ETX0282 can be used for the study of infections caused by drug-resistant Gram-negative bacteria[1][2].
Molekulargewicht:
315.30
CAS Nummer:
[2209871-83-8]
Formel:
C13H18FN3O5
Target-Kategorie:
Beta-lactamase
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
