Roridin E is a glucose-6-phosphatase (G6Pase) inhibitor and antibiotic, and is a metabolic byproduct of Roridin A (HY-N9599). Roridin E induces significant oxidative stress, characterized by depletion of glutathione in vivo, induction of hepatic lipid peroxidation, and inhibition of renal superoxide dismutase activity. Roridin E reduces blood glucose levels in rats, but exhibits acute toxicity (which is enhanced when co-administered with linoleic acid (HY-N0729)) and causes hepatotoxicity in male albino mice. Roridin E induces a decrease in total blood protein and increases in the levels of total lipids, gamma-glutamyltransferase, alkaline phosphatase, and 5-nucleotidase. Roridin E can be isolated from molds, and possesses cytostatic and antifungal activities similar to those of Verrucarin A (HY-107426) and Roridin A. Roridin E exhibits in vivo activity in rodents and is commonly used in hepatotoxicity-related studies[1][2][3].
Molekulargewicht:
514.61
Reinheit:
99.82
CAS Nummer:
[16891-85-3]
Formel:
C29H38O8
Target-Kategorie:
Antibiotic,Fungal,Phosphatase
Anwendungsbeschreibung:
MCE Product type: Natural Products
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