Dasminapant (APG-1387), a bivalent SMAC mimetic and an IAP antagonist, blocks the activity of IAPs family proteins (XIAP, cIAP-1, cIAP-2, and ML-IAP). Dasminapant induces degradation of cIAP-1 and XIAP proteins, as well as caspase-3 activation and PARP cleavage, which leads to apoptosis. Dasminapant can be used for the research of hepatocellular carcinoma, ovarian cancer, and nasopharyngeal carcinoma[1][2][3][4][5].
Molekulargewicht:
1157.40
Reinheit:
99.70
CAS Nummer:
[1570231-89-8]
Formel:
C60H72N10O10S2
Target-Kategorie:
Apoptosis,IAP
Anwendungsbeschreibung:
MCE Product type: Reference compound
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