Cycloartenyl ferulate (Cycloartenol ferulate, Cycloartenol ferulic acid ester) is a derivative of gamma-oryzanol (HY-B2194) with multiple biological activities including antioxidant, anti-inflammatory, and anti-tumor properties. Cycloartenyl ferulate selectively binds to IFNgammaR1 (binding affinity Kd = 0.5 µM) to activate the canonical JAK1/2-STAT1 signaling pathway. Cycloartenyl ferulate inhibits paraquat (PQ)-triggered apoptosis and ROS in HK2 cells. Cycloartenyl ferulate enhances the activation and cytolytic activity of natural killer (NK) cells by upregulating the expression of NK cell activation receptors (NKG2D, NKp30, NKp44) and the release of cytotoxic molecules and cytokine IFNgamma. Cycloartenyl ferulate exerts anti-cancer effects in tumor mice models. Cycloartenyl ferulate can be used for the study of cancer and allergic inflammation intervention[1][2][3].
Molekulargewicht:
602.89
Reinheit:
98.98
CAS Nummer:
[21238-33-5]
Formel:
C40H58O4
Target-Kategorie:
Apoptosis,Drug Derivative,JAK,Reactive Oxygen Species (ROS),STAT
Anwendungsbeschreibung:
Natural Products
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