Narazaciclib (ON123300), a strong and brain-penetrant[1] multi-kinase inhibitor, inhibits CDK4 (IC50=3.9 nM), Ark5 (IC50=5 nM), PDGFRbeta (IC50=26 nM), FGFR1 (IC50=26 nM), RET (IC50=9.2 nM), and FYN (IC50=11 nM). Single agent Narazaciclib causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors[2]. Narazaciclib inhibits CDK6 with an IC50 of 9.82 nM[3].
Molekulargewicht:
429.52
Reinheit:
98.66
CAS Nummer:
[1357470-29-1]
Formel:
C24H27N7O
Target-Kategorie:
AMPK,CDK,PDGFR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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