BI-2852, CAS [[2375482-51-0]]

Produktübersicht

• Artikelname: BI-2852, CAS [[2375482-51-0]]
• Artikelnummer: MCE-HY-126247
• Hersteller Artikelnummer: HY-126247
• Alternativnummer: MCE-HY-126247-5MG,MCE-HY-126247-25MG,MCE-HY-126247-10MG,MCE-HY-126247-10MMX1ML,MCE-HY-126247-50MG,MCE-HY-126247-100MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 µM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

Produkteigenschaften

• Molekulargewicht: 516.59
• Reinheit: 99.57
• CAS Nummer: [2375482-51-0]
• Formel: C31H28N6O2
• Target-Kategorie: Ras

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound