(R)-BI-2852, CAS [[2375482-49-6]]

Produktübersicht

• Artikelname: (R)-BI-2852, CAS [[2375482-49-6]]
• Artikelnummer: MCE-HY-126247B
• Hersteller Artikelnummer: HY-126247B
• Alternativnummer: MCE-HY-126247B-5MG,MCE-HY-126247B-25MG,MCE-HY-126247B-10MG,MCE-HY-126247B-50MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

(R)-BI-2852 is the isomer of BI-2852 (HY-126247), and can be used as an experimental control. BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 µM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

Produkteigenschaften

• Molekulargewicht: 516.59
• Reinheit: 97.32
• CAS Nummer: [2375482-49-6]
• Formel: C31H28N6O2
• Target-Kategorie: Drug Derivative,Ras

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound