A-9758 is a RORgamma ligand and a potent, selective RORgammat inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. A-9758 is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and is effective in blocking skin and joint inflammation[1].
Molekulargewicht:
527.36
CAS Nummer:
[2055271-22-0]
Formel:
C25H23Cl2F3N2O3
Target-Kategorie:
Interleukin Related,ROR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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