GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1.7 inhibitor (Ki of 0.79 nM and Kd of 0.38 nM for hNav1.7) for the treatment of chronic pain. GNE-616 shows >1000 nM Kd and >2500-fold selectivity over hNav1.1, hNav1.3, hNav1.4, and hNav1.5. Selectivity over hNav1.2 and hNav1.6 is more modest at 31- and 73-fold, respectively[1].
Molekulargewicht:
537.53
CAS Nummer:
[2349371-81-7]
Formel:
C24H23F4N5O3S
Target-Kategorie:
Sodium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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