DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 (DMT1) with an IC50 of 0.64 µM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia[1].
Molekulargewicht:
294.31
Reinheit:
99.79
CAS Nummer:
[1354790-56-9]
Formel:
C16H14N4O2
Target-Kategorie:
Ferroportin
Anwendungsbeschreibung:
MCE Product type: Reference compound
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