Phleomycin is a copper-dependent DNA damaging agent and antibiotic with antitumor activity. Phleomycin binds to DNA and produces ROS in the presence of reducing agents (such as dithiothreitol and glutathione), inducing single-strand and double-strand breaks in DNA. Phleomycin can induce cell apoptosis or mutation and is widely used in cancer inhibition, microbial genetic transformation (as a screening marker to improve fungal transformation efficiency) and DNA repair mechanism research[1][2][3].
Reinheit:
95
CAS Nummer:
[11006-33-0]
Target-Kategorie:
Antibiotic,Bacterial,DNA/RNA Synthesis
Anwendungsbeschreibung:
MCE Product type: Natural Products
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