Tedisamil (KC-8857) is an antiarrhythmic compound with important biological activities. Tedisamil exhibits a significant slowing effect on heart rate, which is achieved by inhibiting the transient outward potassium current (I(to)) in the atrium. Tedisamil inhibits multiple potassium currents, including IK, K(ATP), and PKA-activated chloride channels, thereby prolonging the cardiac action potential and QT interval, and increasing cardiac reentry. Tedisamil has antiarrhythmic effects on ventricular arrhythmias and atrial flutter in animal models[1].
Molekulargewicht:
288.47
CAS Nummer:
[90961-53-8]
Formel:
C19H32N2
Target-Kategorie:
Potassium Channel
Anwendungsbeschreibung:
Reference compound
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