PF-06658607 is an alkynylated irreversible Brutons tyrosine kinase (BTK) inhibitor that covalently reacts with active site cysteines in the ATP-binding pocket. PF-06658607 can be used to detect off -targets for covalent kinase inhibitors in cancer cells. The alkyne moiety allows for azide-based detection probe via copper-catalyzed click chemistry[1].
Molekulargewicht:
464.52
Reinheit:
99.69
CAS Nummer:
[1621002-24-1]
Formel:
C27H24N6O2
Target-Kategorie:
Btk
Anwendungsbeschreibung:
MCE Product type: Reference compound
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