Cholic acid 7-sulfate, CAS [[60320-05-0]]

Produktübersicht

• Artikelname: Cholic acid 7-sulfate, CAS [[60320-05-0]]
• Artikelnummer: MCE-HY-126855
• Hersteller Artikelnummer: HY-126855
• Alternativnummer: MCE-HY-126855-10MG,MCE-HY-126855-100MG,MCE-HY-126855-25MG,MCE-HY-126855-5MG,MCE-HY-126855-50MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: 7-Sulfocholic acid

Produktbeschreibung

Cholic acid 7-sulfate (7-Sulfocholic acid) is a selective agonist targeting TGR5 (EC50=0.17 µM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation[1][2].

Produkteigenschaften

• Molekulargewicht: 488.63
• Reinheit: 99.92
• CAS Nummer: [60320-05-0]
• Formel: C24H40O8S
• Target-Kategorie: G protein-coupled Bile Acid Receptor 1,MHC

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound