Prucalopride succinate is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride succinate improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride succinate also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride succinate can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer[1][2][3][4].
Molekulargewicht:
485.96
Reinheit:
99.94
CAS Nummer:
[179474-85-2]
Formel:
C22H32ClN3O7
Target-Kategorie:
5-HT Receptor,Apoptosis,Autophagy
Anwendungsbeschreibung:
MCE Product type: Reference compound
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