U-99194 (PNU-99194) maleate is a selective, potent dopamine D3 receptor antagonist (Ki =160 nM). U-99194 maleate inhibits the activation of D3 receptor mediated by endogenously released dopamine or exogenous D3 agonists. U-99194 maleate abrogates the IPSC-suppressive effect of the D3 agonist PD 128907 in rat hippocampal slices. U-99194 maleate significantly suppresses Nicotine (HY-127019)-induced tremor in mice. U-99194 maleate can be used for the study of dopamine D3 receptor-mediated motor disorders, particularly kinetic tremors[1][2].
Molekulargewicht:
393.47
Reinheit:
99.23
CAS Nummer:
[234757-41-6]
Formel:
C21H31NO6
Target-Kategorie:
Dopamine Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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