Piribedil is a potent and orally active dopamine D2 and dopamine D3 agonist. Piribedil is also a alpha2-adrenoceptors antagonist. Piribedil can inhibit MLL1 methyltransferase activity (EC50: 0.18 µM). Piribedil has the potential for the research of parkinsons disease, circulatory disorders, cancers[1][2][3][4].