Iptacopan (LNP023) is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G)[1][2][3].
Molekulargewicht:
422.52
Reinheit:
99.95
CAS Nummer:
[1644670-37-0]
Formel:
C25H30N2O4
Target-Kategorie:
Complement System
Anwendungsbeschreibung:
MCE Product type: Reference compound
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