BRL-44408 is a selective adrenergic receptor antagonist of alpha2A/alpha2B AR. BRL-44408 can effectively antagonize the inhibitory effects of norepinephrine or adrenergic receptor agonist Clonidine (HY-12721) on K+-induced [3H]norepinephrine and [3H]5-hydroxytryptamine release. BRL-44408 has a higher affinity for human platelet membranes containing alpha2A-adrenoceptors than BRL-41992 and Imiloxan (HY-101337). BRL-44408 may affect the release of norepinephrine and 5-hydroxytryptamine through a mechanism mediated by alpha2A-adrenoceptors, and has a potential role in the regulation of neurotransmitter release[1].
Molekulargewicht:
215.29
CAS Nummer:
[118343-19-4]
Formel:
C13H17N3
Target-Kategorie:
Adrenergic Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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