CARM1-IN-1 (compound 7g) is a highly potent and selective inhibitor of CARM1 (IC50=8.6 µM, CARM1/PABP1), with low inhibitory activity against PRMT1 and SET7 (IC50 >667 µM). CARM1-IN-1 inhibits the methylation activity of CARM1 and the methylation levels of different substrates, such as PABP1, CA150, SmB, and H3. CARM1-IN-1 also inhibits the promoter activity of prostate-specific antigen (PSA) without significant cytotoxicity[1].
Molekulargewicht:
555.26
Reinheit:
95
CAS Nummer:
[1020399-49-8]
Formel:
C26H21Br2NO3
Target-Kategorie:
Histone Methyltransferase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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