Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s of 30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50=20 nM)[1].
Molekulargewicht:
458.36
Reinheit:
99.67
CAS Nummer:
[724453-98-9]
Formel:
C22H17Cl2N3O2S
Target-Kategorie:
Epoxide Hydrolase,FLAP
Anwendungsbeschreibung:
Reference compound
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