ZAK-IN-1 is an orally active and selective selective leucine-zipper and sterile-alpha motif kinase (ZAK) inhibitor with IC50 of 4 nM and KD of 8 nM. ZAK-IN-1 exhibits excellent selectivity against a panel of 403 wild-type kinases. ZAK-IN-1 blocks p38/GATA-4 and JNK/c-Jun signaling and shows promising anti antihypertrophic cardiomyopathy (HCM) efficacy. ZAK-IN-1 can be used for the study of HCM[1].
Molekulargewicht:
559.55
Reinheit:
98.43
CAS Nummer:
[2362525-64-0]
Formel:
C27H19F2N7O3S
Target-Kategorie:
MAP3K
Anwendungsbeschreibung:
Reference compound
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