FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase beta2 with IC50s of 7.7 and 6.5 µM, respectively[1].
Molekulargewicht:
377.43
Reinheit:
98.64
CAS Nummer:
[1646682-14-5]
Formel:
C23H23NO4
Target-Kategorie:
Complement System
Anwendungsbeschreibung:
MCE Product type: Reference compound
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