PI3K-IN-4 is a potent Pan-PI3K inhibitor. PI3K-IN-4 has high activity for three PI3K isoforms with the IC50 values of picomole. PI3K-IN-4 shows superior inhibitory activity against PI3Kalpha (IC50 = 0.20 nM), PI3Kbeta (IC50 = 2.99 nM), PI3Kdelta (IC50 = 0.48 nM) and PI3Kgamma (IC50 = 0.58 nM) and has no significant activity against EGFR. PI3K-IN-4 inhibits cancer cell growth though PI3K/Akt signaling pathway, leading to the inhibition of colony formation and the induction of apoptosis. PI3K-IN-4 can be used for lung, colon and breast cancer research[1].
Molekulargewicht:
553.54
CAS Nummer:
[2269470-35-9]
Formel:
C25H21F2N7O4S
Target-Kategorie:
Akt,Apoptosis,PI3K
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
