IDH1 Inhibitor 2 (compound 13) is a potent wild-type IDH1 inhibitor that exerts its activity through covalent modification of His315 with an IC50 value of 110 nM. IDH1 Inhibitor 2 can dose-dependently reduce the intracellular reduced glutamine metabolic flux, thereby affecting cellular metabolic homeostasis. IDH1 Inhibitor 2 can be used to study the role of IDH1 in cellular metabolic regulation and cancer development[1][2].
Molekulargewicht:
406.48
Reinheit:
99.40
CAS Nummer:
[2244895-42-7]
Formel:
C26H22N4O
Target-Kategorie:
Isocitrate Dehydrogenase (IDH)
Anwendungsbeschreibung:
Reference compound
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