CHK1-IN-4 hydrochloride is a selective checkpoint kinase 1 (Chk1) inhibitor with an IC50 1 nM. The IC50 value of CHK1-IN-4 hydrochloride against Chk2 ranges from 50 to 100 nM. CHK1-IN-4 hydrochloride inhibits cancer cell proliferation and exhibits antitumor activity in colon cancer xenograft models. CHK1-IN-4 hydrochloride can be used for the research of colon cancer and breast cancer[1].
Molekulargewicht:
480.75
Reinheit:
98.02
Formel:
C18H19BrClN7O2
Target-Kategorie:
Checkpoint Kinase (Chk)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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