IWP-4 is a Wnt inhibitor with an IC50 of 25 nM. IWP-4 specifically inhibits casein kinase 1delta/epsilon (CK1delta/epsilon), with an IC50 of 1.06 µM against wild-type CK1delta, 1.02 µM against the CK1delta kinase domain, and 7.07 µM against CK1epsilon, it shows enhanced inhibitory activity against the M82F CK1delta mutant (IC50 = 0.14 µM). IWP-4 is applicable to research related to cancer, Alzheimers disease (AD), and heart failure[1][2][3].
Molekulargewicht:
496.62
Reinheit:
99.81
CAS Nummer:
[686772-17-8]
Formel:
C23H20N4O3S3
Target-Kategorie:
Casein Kinase,Wnt
Anwendungsbeschreibung:
MCE Product type: Reference compound
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