PROTAC MDM2 Degrader-1 (Compound 15a) is a MDM2 PROTAC degrader. The structures of both Linker ends of PROTAC MDM2 Degrader-1 are MDM2 ligands. PROTAC MDM2 Degrader-1 can not only block the binding of p53-MDM2, but also degrade the target MDM2 protein by utilizing the function of the E3 ligase of MDM2 itself, thus exerting an anti-tumor effect. (Pink: MDM2 ligand 2 (HY-128836), Black: Linker (HY-128844), Blue: E3 ligase Ligand 15 (HY-128836))[1]
Molekulargewicht:
1463.33
Reinheit:
98.11
CAS Nummer:
[2249944-98-5]
Formel:
C74H84Cl4N10O13
Target-Kategorie:
MDM-2/p53,PROTACs
Anwendungsbeschreibung:
Reference compound
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