(S,R)-GSK321, CAS [[1816272-18-0]]

Produktübersicht

• Artikelname: (S,R)-GSK321, CAS [[1816272-18-0]]
• Artikelnummer: MCE-HY-128888B
• Hersteller Artikelnummer: HY-128888B
• Alternativnummer: MCE-HY-128888B-100MG,MCE-HY-128888B-50MG,MCE-HY-128888B-5MG,MCE-HY-128888B-10MG,MCE-HY-128888B-25MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

(S,R)-GSK321 is the (S,R)-enantiomer of GSK321 (HY-18948). GSK321 is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. GSK321 induces decrease in intracellular 2-HG, abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. GSK321can be used for research of acute myeloid leukemia (AML) and other cancers[1].

Produkteigenschaften

• Molekulargewicht: 501.55
• Reinheit: 98.62
• CAS Nummer: [1816272-18-0]
• Formel: C28H28FN5O3
• Target-Kategorie: Isocitrate Dehydrogenase (IDH)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound