Poloxin-2 is a small molecule Plk1 PBD inhibitor that can effectively induce cell mitotic arrest with an EC50 of approximately 15 µM in HeLa cells. Poloxin-2HT was developed by conjugating a hydrophobic tag (HT) to Poloxin-2, a new application of inhibitors targeting protein-protein interactions. Poloxin-2HT significantly enhanced the effects on cell viability and apoptosis by selectively degrading Plk1 protein, and its effect was stronger than that of untagged Poloxin-2. These data validate hydrophobic tags as a new strategy for targeting and disrupting disease-associated proteins.
Molekulargewicht:
269.30
CAS Nummer:
[321695-37-8]
Formel:
C16H15NO3
Target-Kategorie:
Polo-like Kinase (PLK)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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