APHS is a specific and covalent COX-2 inhibitor with neuroprotective effects. COX-2 is a prostaglandin (PG) synthetase overexpressed in colorectal cancer (CRC) and has pleiotropic cancer-promoting effects. APHS modifies COX-2 by acetylating the active site (serine 516), thereby inhibiting prostaglandin production. The neuroprotective activity of APHS is inhibited by prostaglandin E2. APHS also co-inhibits the WNT pathway, an anti-tumor mechanism in addition to COX-2 inhibition[1][2].
Molekulargewicht:
262.37
Reinheit:
99
CAS Nummer:
[209125-28-0]
Formel:
C15H18O2S
Target-Kategorie:
COX,Wnt
Anwendungsbeschreibung:
MCE Product type: Reference compound
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