CLH304a, CAS [[1611483-29-4]]

Produktübersicht

• Artikelname: CLH304a, CAS [[1611483-29-4]]
• Artikelnummer: MCE-HY-129636
• Hersteller Artikelnummer: HY-129636
• Alternativnummer: MCE-HY-129636-10MG,MCE-HY-129636-5MG,MCE-HY-129636-1MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: (E)-GABAB receptor antagonist 1

Produktbeschreibung

CLH304a (compound 14) is a specific and noncompetitive GABAB receptor negative allosteric modulator (NAM). CLH304a decreases GABA-induced IP3 production with an IC50 of 37.9 µM. CLH304a has no effect on other GPCR Class C members such as mGluR1, mGluR2, and mGluR5. CLH304a acts on the heptahelical domain of GB2 subunits and non-competitively inhibits the effect of agonists with inverse agonist properties. CLH304a inhibits Baclofen (HY-B0007)-induced ERK1/2 phosphorylation in HEK293 cells overexpressing GABAB receptor[1][2].

Produkteigenschaften

• Molekulargewicht: 304.38
• Reinheit: 99.64
• CAS Nummer: [1611483-29-4]
• Formel: C18H24O4
• Target-Kategorie: ERK,GABA Receptor

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound