2-AEMP (2-Aminoethyl methylphosphonate) is an anti-GABA(A)-rho1 receptor compound with antagonist activity. 2-AEMP exhibits competitive inhibition compared to TPMPA with an IC(50) value of 18 µM, compared to 7 µM for TPMPA. The release rate of inhibition at termination of 2-AEMP is significantly higher than that of TPMPA. The preincubation time required for the onset of inhibition of 2-AEMP is much shorter than that of TPMPA. Some analogs of 2-AEMP, especially those with benzyl or n-butyl substituents, show lower potency in terms of biological activity[1].
Molekulargewicht:
139.09
CAS Nummer:
[321882-95-5]
Formel:
C3H10NO3P
Target-Kategorie:
GABA Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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