GNE-987, CAS [[2417371-71-0]]

Produktübersicht

• Artikelname: GNE-987, CAS [[2417371-71-0]]
• Artikelnummer: MCE-HY-129937A
• Hersteller Artikelnummer: HY-129937A
• Alternativnummer: MCE-HY-129937A-1MG,MCE-HY-129937A-5MG,MCE-HY-129937A-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

GNE-987 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. GNE-987 exhibits picomolar cell BRD4 degradation activity (DC50=0.03 nM for EOL-1 AML cell line). GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities (IC50=4.7 and 4.4 nM, respectively). GNE-987 incorporates a potent BET binder/inhibitor, a VHL-binding fragment, and a ten methylene spacer moiety. GNE-987 can be used in PROTAC-Antibody Conjugate (PAC)[1].

Produkteigenschaften

• Molekulargewicht: 1096.31
• Reinheit: 99.98
• CAS Nummer: [2417371-71-0]
• Formel: C56H67F2N9O8S2
• Target-Kategorie: Epigenetic Reader Domain,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound