Quizartinib (Standard) is the analytical standard of Quizartinib. This product is intended for research and analytical applications. Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis[1].
Molekulargewicht:
560.67
CAS Nummer:
[950769-58-1]
Formel:
C29H32N6O4S
Target-Kategorie:
Apoptosis,Autophagy,FLT3,Ligands for Target Protein for PROTAC,Reference Standards
Anwendungsbeschreibung:
MCE Product type: Reference Standards
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