GCN2-IN-6 (Compound 6d) is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1.8 nM) and cellular assays (IC50 of 9.3 nM). GCN2-IN-6 is also a eIF2alpha kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells)[1]. GCN2-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Molekulargewicht:
485.29
Reinheit:
98.89
CAS Nummer:
[2183470-09-7]
Formel:
C19H12Cl2F2N4O3S
Target-Kategorie:
Eukaryotic Initiation Factor (eIF)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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