Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].
Molekulargewicht:
432.53
Reinheit:
99.46
CAS Nummer:
[217817-01-1]
Formel:
C20H32O8S
Target-Kategorie:
PROTAC Linkers
Anwendungsbeschreibung:
MCE Product type: Reference compound
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