CDDO-TFEA (RTA 404, TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier. CDDO is an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells. CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models, including those mimicking multiple sclerosis, amyotrophic lateral sclerosis, and Huntingtons disease. CDDO-TFEA induces apoptosis and blocks colony formation in Ewings sarcoma and neuroblastoma cell lines with IC50 values ranging from 85-170 nM.
Molekulargewicht:
572.70
Reinheit:
99.59
CAS Nummer:
[932730-52-4]
Formel:
C33H43F3N2O3
Target-Kategorie:
Apoptosis,Keap1-Nrf2
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
