Pomalidomide 4-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1 degrader based on Rucaparib by using the PROTAC approach[1]. Pomalidomide 4-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Molekulargewicht:
474.47
Reinheit:
96.29
CAS Nummer:
[2271036-46-3]
Formel:
C21H26N6O7
Target-Kategorie:
E3 Ligase Ligand-Linker Conjugates
Anwendungsbeschreibung:
MCE Product type: Reference compound
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