PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 µM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with Cereblon ligand[1].
Molekulargewicht:
815.84
Reinheit:
99.85
CAS Nummer:
[2408641-24-5]
Formel:
C40H41N13O7
Target-Kategorie:
CDK,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
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