Selnoflast (RO7486967) monopotassium, formerly somalix/RG6418/IZD334 monopotassium, is an orally active, potent, selective and reversible small molecule NLRP3 inflammasome inhibitor. Selnoflast monopotassium is a potent inhibitor of IL-1beta release stimulated by NLRP3 activation in human Alzheimers disease (AD) monocyte-derived macrophages. Selnoflast monopotassium is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease[1][2][3].
Molekulargewicht:
429.62
CAS Nummer:
[2260969-37-5]
Formel:
C20H28KN3O3S
Target-Kategorie:
Interleukin Related,NOD-like Receptor (NLR)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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