Bardoxolone methyl, CAS [[218600-53-4]]

Produktübersicht

• Artikelname: Bardoxolone methyl, CAS [[218600-53-4]]
• Artikelnummer: MCE-HY-13324
• Hersteller Artikelnummer: HY-13324
• Alternativnummer: MCE-HY-13324-5MG,MCE-HY-13324-500MG,MCE-HY-13324-10MG,MCE-HY-13324-100MG,MCE-HY-13324-10MMX1ML,MCE-HY-13324-200MG,MCE-HY-13324-50MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: RTA 402, NSC 713200, CDDO Methyl ester

Produktbeschreibung

Bardoxolone (CDDO, RTA 401) methyl is an orally active and brain-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC50 value of 0.29 µM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFkappaB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic kidney disease (CKD)[1][2][3][4][5].

Produkteigenschaften

• Molekulargewicht: 505.69
• Reinheit: 99.66
• CAS Nummer: [218600-53-4]
• Formel: C32H43NO4
• Target-Kategorie: Keap1-Nrf2,SARS-CoV,Virus Protease

Anwendungsbeschreibung

• Anwendungsbeschreibung: Reference compound