Monoethyl phthalate is an oraly acitve PDX-1 activator and the major hydrolytic metabolite of Diethyl phthalate (HY-Y0284) in vivo, with reproductive toxicity. Monoethyl phthalate targets aromatase (aromatase/CYP19A1) and PPAR to induce cell proliferation. The plasma protein binding rate of Monoethyl phthalate in rats and humans is lower than that of Diethyl phthalate. It exhibits significant enterohepatic circulation in rats and mainly accumulates in liver tissues. Monoethyl phthalate shows no estrogenic activity in estrogen-dependent human breast cancer cells. Monoethyl phthalate can be used in studies of reproductive toxicity and related environmental endocrine disruption mechanisms[1][2][3].
Molekulargewicht:
194.19
Reinheit:
98.58
CAS Nummer:
[2306-33-4]
Formel:
C10H10O4
Target-Kategorie:
Cytochrome P450,Drug Metabolite,PPAR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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