Capmatinib (INC280, INCB28060) hydrochloride is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib hydrochloride can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib hydrochloride potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib hydrochloride is largely metabolized by CYP3A4 and aldehyde oxidase[1][2][3].
Reinheit:
99.60
CAS Nummer:
[1029714-89-3]
Formel:
C23H17FN6O.xClH
Target-Kategorie:
Apoptosis,c-Met/HGFR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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