Nanatinostat (CHR-3996) is a potent, class I selective and orally active HDAC inhibitor with IC50s of 3 nM, 4 nM, and 7 nM for HDAC1, HDAC2, and HDAC3, respectively. Nanatinostat has low activity against HDAC5 (IC50 of 200 nM) and HDAC6 (IC50 of 2100 nM). Nanatinostat induces apoptosis in myeloma cells. Nanatinostat has potent anticancer effects, such as myeloma, advanced solid tumours and colorectal cancer[1][2][3].
Molekulargewicht:
394.40
Reinheit:
99.67
CAS Nummer:
[1256448-47-1]
Formel:
C20H19FN6O2
Target-Kategorie:
Apoptosis,HDAC
Anwendungsbeschreibung:
MCE Product type: Reference compound
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