TNF-alpha-IN-2 is a potent and orally active inhibitor of tumor necrosis factor alpha (TNFalpha), with an IC50 of 25 nM in the HTRF assay. TNF-alpha-IN-2 distorts the TNFalpha trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-alpha-IN-2 can be used for the research of rheumatoid arthritis[1].
Molekulargewicht:
494.92
Reinheit:
99.2
CAS Nummer:
[2074702-04-6]
Formel:
C25H21ClF2N6O
Target-Kategorie:
TNF Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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