5-HT7/5-HT2A receptor antagonist 1, CAS [[851375-22-9]] Preis auf Anfrage
Artikelnummer:
MCE-HY-134483
Hersteller Artikelnummer:
HY-134483
Alternativnummer:
MCE-HY-134483-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
5-HT7/5-HT2A receptor antagonist 1 is a high-affinity, orally active, brain-penetrant 5-HT7 and 5-HT2A receptor ligand having a pKi = 8.1 at both receptors. 5-HT7/5-HT2A receptor antagonist 1 behaves as an antagonist in an in vitro functional assay for 5-HT2A and as an inverse agonist in an in vitro functional assay for 5-HT7. 5-HT7/5-HT2A receptor antagonist 1 blockade of 5-Carboxamidotryptamine (5-CT) (HY-135555) induced hypothermia in rats, and blockade of 2,5-dimethoxy-4-iodoamphetamine (DOI) induced head-twitches in mice. 5-HT7/5-HT2A receptor antagonist 1 occupied 5-HT2A receptor binding sites in the frontal cortex of the rat brain. 5-HT7/5-HT2A receptor antagonist 1 can be used for the study of Neurological diseases[1].
Molekulargewicht:
273.35
CAS Nummer:
[851375-22-9]
Formel:
C16H20FN3
Target-Kategorie:
5-HT Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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