AM-1638 is an orally active full agonist of GPR40 (EC50: 0.16 µM). AM-1638 increases the expression of antioxidant molecules (HO-1 and NQO-1). AM1638 blocks Palmitate (HY-N0830)-mediated superoxide production and ER stress. AM-1638 has antidiabetic activity and improves glycemic control in BDF mice with diet-induced obesity (DIO). AM-1638 demonstrates excellent oral bioavailability (mouse, >100%, rat, 72%, and cyno, 71%)[1][2][3].
Molekulargewicht:
514.63
Reinheit:
99.65
CAS Nummer:
[1142214-62-7]
Formel:
C33H35FO4
Target-Kategorie:
Free Fatty Acid Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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