(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-kappaB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans[1][2][3].
Molekulargewicht:
384.24
Reinheit:
97
CAS Nummer:
[1132709-14-8]
Formel:
C19H25BN4O4
Target-Kategorie:
Apoptosis,Proteasome
Anwendungsbeschreibung:
MCE Product type: Reference compound
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