DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-lambdaB affinity, KD of 12 nM) in vitro. DB1976 has apoptosis-inducing effect[1][2][3].
Molekulargewicht:
447.35
CAS Nummer:
[1557397-51-9]
Formel:
C20H16N8Se
Target-Kategorie:
Apoptosis
Anwendungsbeschreibung:
MCE Product type: Reference compound
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